What are Causes of Nasal Polyp Formation ???
The prime histological feature of nasal polyps is a massive infiltration of eosinophils and eosinophil is considered to be present in 86% of all nasal polyps. Recent studies have suggested that the airway epithelium plays an important role in the patho genesis of inflammatory airway diseases. This suggests that factors leading to the development of nasal polyposis include pathophysiological changesin electrolyte and water transport in the surface epithelium. Furthermore, it has been suggested that a fungaletiology may underlie severe nasal polyposis, although this notion is still controversial. As apossible mechanism by which fungi act on therespiratory epithelium, it has been suggested that fungi produce proteases that bind toprotease-activated receptors; this binding would activate intracellular signalling path ways thatwould give rise to multiple responses, including cytokine production and disruption of tight junctions Glucocorticoids are known to be ef...